|
No. |
Reference |
|
1 |
Data on file, Medtrade. In laboratory testing Celox was effective on heparinized blood, blood at 56 °F blood temperature and did not increase in temperature during use. |
|
2 |
Tan ECTH, Bleeker CP. Field experience with a chitosan-based hemostatic dressing. MCI Forum. 2011; 3/4-2011: 34-39. |
|
3 |
Pozza M, Millner R. Celox (chitosan) for hemostasis in massive traumatic bleeding: experience in Afghanistan. Eur J Emerg Med. 2011; 18: 31-33. |
|
4 |
Observed in laboratory testing. Medtrade data on file. |
|
5 |
Rall J et al. Comparison of novel hemostatic dressings with QuikClot combat gauze in a standardized swine model of uncontrolled haemorrhage. J Trauma. 2013; 75: S150 – S156 |
|
6 |
Littlejohn LF et al. Comparison of Celox-A, ChitoFlex, WoundStat and Combat Gauze hemostatic agents versus standard gauze dressing in control of hemorrhage in a swine model of penetrating trauma. Acad Emer Med. 2011; 18: 340-350. |
|
7 |
Kozen B et al. An Alternative Hemostatic Dressing: Comparison of CELOX, HemCon and QuikClot. Acad Emer Med. 2008; 15:74-81. |
|
8 |
Product instructions for use. |
|
9 |
Kunio N et al. Chitosan based advanced hemostatic dressing is associated with decreased blood loss in swine uncontrolled hemorrhage model. Am J Surg. 2013; 205:505-510. |
|
10 |
Hoggarth A et al. Mechanism of action of a rapid-acting gauze hemostat. Poster presentation at ATACCC 2011, Fort Lauderdale, FL. |
|
11 |
Nancy Caroline’s Emergency Care in the Streets. Nancy Caroline. Jones & Bartlett, Sudbury MA 2008. |
|
12 |
DoD test results reference based on 10’ Celox™Gauze. |
|
13 |
CDC/NCHS, Health United States 2013, Data from National Health and Nutritional Examination Survey. |
|
14 |
Contains chitosan from shellfish – allergy studies show no adverse reactions – data on file. |
|
15 |
Johnson L et al. The in vivo assessment of an unusual new hemostat technology.” Presented at SAWC, April 2008, San Diego. |
|
16 |
Peng T. Biomaterials for hemorrhage control. Trends Biomat Artif Organs. 2010; 24(1): 27-68. |
|
17 |
Millner R, Lockhart A. Omni-stat (chitosan) arrests bleeding in heparinised subjects in vivo: an experimental study in a model of major peripheral vascular injury. Eur J Cardiothorac Surg 2011; 39(6): 952-954. |
|
18 |
Waibel KH et al. Safety of chitosan bandages in shellfish allergic patients. Mil Med 2011; 176: 1153-6. |
|
19 |
Baldrick P. The Safety of Chitosan as a pharmaceutical excipient. Regul Toxicol Pharmacol 2010; 56(3):290-9. |
|
20 |
Scherle C, Krol J. Can new hemostatic dressings facilitate sharp debridement in high-risk patients? Podiatry Today 2009; 22(7):20-22. |
|
21 |
Snyder RJ, Sigal BD. An open-label controlled clinical study of OMNI-STAT (Chitosan) versus standard of care in post-debridement treatment of patients with chronic wounds with or without concomitant use of anticoagulants. Wound Care and Hyperbaric Medicine 2013; 4(2): 9-16. |
|
22 |
Medtrade Data on File |
|
23 |
Eastridge B et al. Death on the battlefield (2001Y2011): Implications for the future of combat casualty care. J Trauma 2012; 73(6): S431-S437. |
|
24 |
Watters JM et al. Advanced hemostatic dressings are not superior to gauze for care under fire scenarios. J Trauma 2011;70:1413-1419. |
|
25 |
https://archive.ahrq.gov/news/newsletters/research-activities/jan10/0110RA1.html Accessed 13 Feb. 2017 |
|
26 |
Celox hemostatic gauze is approved by the Department of Defense for military use. |
|
27 |
Kauvar, D.S., Lefering, R., and Wade, C.E. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006;60: S3-11 |
|
28 |
Arul GS, Bowely DM, DiRusso S. The use of Celox Gauze as an adjunct to pelvic packing in otherwise uncontrollable pelvic haemorrhage secondary to penetrating trauma. J R Army Med Corps 2012. 158(4): 331-334. |
|
29 |
Quayle JM, Thomas GOR. A Pre-hospital Technique for Controlling Haemorrhage from Traumatic Perineal and High Amputation Injuries. JR Army Med Corps 157(4): 419-420. |
|
30 |
Bennett BL, Littlejohn LF, Kheirabadi BS, Butler FK, Kotwal RS, Dubick MA, Bailey JA. Management of External Hemorrhage in Tactical Combat Casualty Care: Chitosan-Based Hemostatic Gauze Dressings, TCCC Guidelines – Change 13-05. J Special Operations Medicine. 2014; 14(3): 12-29. |
|
31 |
National Trauma Institute : |
|
32 |
From Center for Disease Control and Prevention. https://www.cdc.gov/injury/wisqars/overview/key_data.html . Accessed 14 Feb 2017. |
|
33 |
Koksal O et l. Hemostatic effect of a chitosan linear polymer (Celox) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy. Turk J Trauma & Emerg Surg. 2011; 17:199-204. |
|
34 |
Khoshmohabat H, et al. Overview of agents used for emergency hemostasis |
|
35 |
Muzzi et al Successful use of a military haemostatic agent in patients undergoing extracorporeal circulatory assistance and delayed sternal closure. Interact Cardiovasc Thorac Surg. 2012;14(6):695-8. |
|
36 |
Rao SB, Sharma CP. Use of chitosan as a biomaterial: studies on its safety and hemostatic potential. J Biomed Mater Res. 1997; 34(1):21-8 |
|
37 |
Aiba S. Studies on chitosan: 4. Lysozymic hydrolysis of partially N-acetylated chitosans. Int J Biol Macromol 1992 vol 14, August. |
|
38 |
UK MOD selects Celox Rapid as haemostat of choice: https://www.celoxmedical.com/uk-mod-selects-celox-rapid/ |
|
TM |
Trademark of Medtrade Products Limited |
|
* |
Combat Gauze Trademark of Z-Medica |
|
** |
Chitogauze Trademark of Hemcon |
|
*** |
Bolin Trademark of H&H Medical Corporation |
|
**** |
Halo Trademark of Medical Devices inc |
