Celox™ Technology

Origins of CELOX 

CELOX is proven to stop life-threatening bleeding fast – and is trusted by militaries, emergency services and healthcare professionals worldwide for over 18 years.

When a wound is haemorrhaging, blood escapes from the circulatory system at the wound site, the body then attempts to stop the haemorrhage via the intrinsic and extrinsic clotting pathways, which results in the formation of a stable clot.

Patients who have suffered major blood loss are at significant risk of becoming coagulopathic, a medical condition that causes the body’s natural clotting mechanism to become ineffective. 

Studies support that CELOX works independently of the body’s natural clotting cascade4 and has been shown to work even in the presence of clotting dysfunction4.

Some other haemostats on the market work by accelerating the body’s clotting cascade which may become compromised during major blood loss.  CELOX works independently of this process.

CELOX is designed to help stop life-threatening bleeding quickly and reliably.

Post-Partum Haemorrhage 

Safe and clinically effective supported by a range of peer reviewed published clinical papers1, 2, 3 

After years of effectively employing CELOX™ gauze in rigorous settings like trauma, military and emergency care, a promising opportunity emerged in the realm of PPH. There are significant global challenges associated with PPH which unpinned our drive and passion to support research and development across reproductive health, to produce a versatile, easy to use, cost effective, clinically successful device.

The journey towards the creation of CELOX™ PPH commenced with an exhaustive research and development phase where it underwent scrupulous testing and assessment over a period of 10+ years, ensuring its utmost safety and effectiveness in intrauterine applications.

This evolution from military use to the delivery room serves as a testament to CELOX™ technology’s versatility and adaptability and its unwavering commitment to saving lives, regardless of the setting. It stands as a prime example of how advancements developed in one arena can be harnessed to make a transformative difference in another, ultimately benefiting individuals and communities around the world.

FAST ACTING
SAFE
EFFECTIVE
VERSATILE
EASY TO USE

Mode of Action 

When applied directly to the site of bleeding Celox Granules: 

  1. The granules absorb fluid from the blood to form a robust gel-like plug.
  2. Concentrating the red blood cells and plasma to create a robust mechanical gel-like clot that plugs the bleeding source.
  3. The granules exhibit a level of mucoadhesion to the surrounding tissue, which keeps the gel plug in place
  4. Creating an environment which allows clot formation under the gel plug. 

Absorb Fluid  Form Gel Plug Adhere to Tissue  Create clot

References:

1. Schmid BC, Rezniczek GA, Rolf N, et al. Uterine packing with chitosan-covered gauze for control of postpartum hemorrhage Am J Obstet Gynecol 2013;209:225.e1-5.

2. A.M. Dueckelmann et al. Uterine packing with chitosan-covered gauze compared to balloon tamponade for managing postpartum hemorrhage, European Journal of Obstetrics & Gynecology and Reproductive Biology 240 (2019) 151-155.

3. C. Biele et al., “Does the use of chitosan covered gauze for postpartum hemorrhage reduce the need for surgical therapy including hysterectomy? A databased historical cohort study,” (in eng), J Perinat Med, May 25 2022, doi: 10.1515/jpm-2021-0533.

4. Millner R, Lockhart AS, Marr R. Chitosan arrests bleeding in major hepatic injuries with clotting dysfunction: an in vivo experimental study in a model of hepatic injury in the presence of moderate systemic heparinisation. Ann R Coll Surg Engl. 2010 Oct;92(7):559-61. doi: 10.1308/003588410X12699663903593. Epub 2010 Jun 1. PMID: 20522310; PMCID: PMC3229344.

5. Morrison CA. The prehospital treatment of the bleeding patient – dare to dream. J Surg Res. 2013;180(2):246–7. (In-vivo).

6. Sharrock AE, et al. Combat vascular injury: influence of mechanism of injury on outcome. Injury 2018. Doi: 10.1016/j.injury.2018.06.037 (Retrospective Stats-cohort study).

7. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet. 1997;349(9064):1498–504 (Retrospective Stats).

8. Donley ER, Loyd JW. Hemorrhage control. NCBI Bookshelf. StatPearls Publishing: 2021.

9. Winstanley M, Smith JE, Wright C. Catastrophic haemorrhage in military major trauma patients: a retrospective database analysis of haemostatic agents used on the battlefield. J R Army Med Corps 2018;0:1-5 (In-vivo).

10. CELOX. UK MoD Selects Celox Rapid Haemostatic Gauze for all Branches of the UK Military. Cision PR Newswire, 31 Jan, 2018, 15:48 GMT. Available at: https://prn.to/2J51zsI . Accessed September 2019.

11. TCCC Guidelines – https://tccc.org.ua/files/downloads/clinical-guidelines-2024-en.pdf

 

 

Despite significant advancements in scientific understanding and technology, trauma remains a leading cause of human morbidity and mortality5, with haemorrhage as a major cause of preventable death in combat and civilian trauma situations6,7,8. The CELOXTM range helps to speed up urgent medical care required on the battlefield and civilian emergency situations.

 

CELOXTM products utilise the same advanced chitosan-based technology, developed through years of collaboration between our highly skilled team and military and civilian trauma experts, to effectively prevent major haemorrhages in the field.

CELOXTM products are designed for the tough demands of tactical medicine and are also the perfect size for an Individual First Aid Kit. CELOXTM Products are used across several NATO forces and other military forces as seen during combat operations in Iraq and Afghanistan9. CELOXTM Rapid is the UK Ministry of Defence’s product of choice10 and CELOXTM Gauze has been approved and listed in the TCCC Guidelines by the US CoTCCC committee11.

CELOXTM – MILITARY AND CIVILIAN EMERGENCY SITUATIONS

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Made To Save Lives

CELOX Medical Trading name of

Medtrade Products Ltd,
Electra House, Crewe Business Park,
Crewe,
UK,
CW1 6GL

Tel:  +44 (0)1270 500019

OMNI-STAT Medical

New York – SoHo – Hudson Square,
101 Avenue of the Americas,
8th and 9th Floors,
New York, USA,
NY 10013

Tel:  +1 646 417 8452

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